The Kansas City Chiefs selected Moore in the second round (54th overall) of the 2022 NFL Draft.
Moore appeared in 16 games, of which he started three, as a rookie. He finished with 22 receptions for 250 receiving yards. In the final minute of the AFC Championship Game against the Cincinnati Bengals, Moore returned a punt return 29 yards, just three yards shy of midfield, which helped set up Harrison Butker’s game-winning 45 yard field goal to secure a 23–20 victory and propel the Chiefs to Super Bowl LVII. In Super Bowl LVII, Moore scored his first career touchdown in the fourth quarter of the Chiefs 38–35 victory over the Philadelphia Eagles.